Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting
Identifieur interne : 005570 ( Main/Exploration ); précédent : 005569; suivant : 005571Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting
Auteurs : Jochen Schmitt [Allemagne] ; Phyllis Spuls [Pays-Bas] ; Maarten Boers [Pays-Bas] ; Kim Thomas [Royaume-Uni] ; Joanne Chalmers [Royaume-Uni] ; Evelien Roekevisch [Pays-Bas] ; Mandy Schram [Pays-Bas] ; Richard Allsopp [Royaume-Uni] ; Valeria Aoki [Brésil] ; Christian Apfelbacher [Allemagne] ; Carla Bruijnzeel-Koomen [Pays-Bas] ; Marjolein Bruin-Weller [Pays-Bas] ; Carolyn Charman [Royaume-Uni] ; Arnon Cohen [Israël] ; Magdalene Dohil [États-Unis] ; Carsten Flohr [Royaume-Uni] ; Masutaka Furue [Japon] ; Uwe Gieler [Allemagne] ; Lotty Hooft [Pays-Bas] ; Rosemary Humphreys [Royaume-Uni] ; Henrique Akira Ishii [Brésil] ; Ichiro Katayama [Japon] ; Willem Kouwenhoven [Pays-Bas] ; Sinéad Langan [Royaume-Uni] ; Sue Lewis-Jones [Royaume-Uni] ; Stephanie Merhand [France] ; Hiroyuki Murota [Japon] ; Dedee F. Murrell [Australie] ; Helen Nankervis [Royaume-Uni] ; Yukihiro Ohya [Japon] ; Arnold Oranje [Pays-Bas] ; Hiromi Otsuka [Japon] ; Carle Paul [France] ; Yael Rosenbluth [Israël] ; Hidehisa Saeki [Japon] ; Marie-Louise Schuttelaar [Pays-Bas] ; Jean-Francois Stalder [France] ; Ke Svensson [Suède] ; Roberto Takaoka [Brésil] ; Carl-Fredrik Wahlgren [Suède] ; Stephan Weidinger [Allemagne] ; Andreas Wollenberg [Allemagne] ; Hywel Williams [Royaume-Uni]Source :
- Allergy [ 0105-4538 ] ; 2012-09.
Descripteurs français
- Wicri :
- topic : Allergie, Industrie pharmaceutique.
English descriptors
- KwdEn :
- Adequate measurements, Allergy, Ares, Atopic, Atopic dermatitis, Atopic eczema, Atopic eczema outcomes research, Atopic eczema research, Atopic eczema trials, Biomarkers, Clinical signs, Clinical trials, Consensus, Consensus study, Consensus voting, Core domain, Core domains, Core outcome domain, Core outcome domains, Core outcome measures, Delphi, Delphi exercise, Dermatitis, Dermatol, Dermatology, Disease severity, Domain, Eczema, Future atopic eczema trials, Harmonising outcome measures, Home group, Home initiative, Hywel williams, Jochen schmitt, John wiley sons, John wiley sons schmitt, Omeract, Omeract group, Outcome domains, Outcome measures, Outcomes research, Patient representatives, Pharmaceutical industry, Pharmaceutical industry representatives, Phyllis spuls, Preliminary core, Schmitt, Severity, Severity index, Spuls, Stakeholder, Systematic review, Treatment utilization.
- Teeft :
- Adequate measurements, Allergy, Ares, Atopic, Atopic dermatitis, Atopic eczema, Atopic eczema outcomes research, Atopic eczema research, Atopic eczema trials, Biomarkers, Clinical signs, Clinical trials, Consensus, Consensus study, Consensus voting, Core domain, Core domains, Core outcome domain, Core outcome domains, Core outcome measures, Delphi, Delphi exercise, Dermatitis, Dermatol, Dermatology, Disease severity, Domain, Eczema, Future atopic eczema trials, Harmonising outcome measures, Home group, Home initiative, Hywel williams, Jochen schmitt, John wiley sons, John wiley sons schmitt, Omeract, Omeract group, Outcome domains, Outcome measures, Outcomes research, Patient representatives, Pharmaceutical industry, Pharmaceutical industry representatives, Phyllis spuls, Preliminary core, Schmitt, Severity, Severity index, Spuls, Stakeholder, Systematic review, Treatment utilization.
Abstract
The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence‐based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence‐based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long‐term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research.
Url:
DOI: 10.1111/j.1398-9995.2012.02874.x
Affiliations:
- Allemagne, Australie, Brésil, France, Israël, Japon, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, Californie, District de Dresde, District de Haute-Bavière, District de Karlsruhe, Grand Londres, Groningue (province), Hollande-Méridionale, Hollande-Septentrionale, Kyūshū, Midi-Pyrénées, Nottinghamshire, Nouvelle-Galles du Sud, Occitanie (région administrative), Pays de la Loire, Préfecture de Fukuoka, Région de Kantō, Saxe (Land), Schleswig-Holstein, Utrecht (province), État de São Paulo
- Amsterdam, Dresde, Fukuoka, Groningue, Heidelberg, Kiel, Londres, Munich, Nantes, Nottingham, Rotterdam, San Diego, Sydney, São Paulo, Tokyo, Toulouse, Utrecht
- Université de Kyūshū, Université de Nottingham, Université de São Paulo
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type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Schram, Mandy" sort="Schram, Mandy" uniqKey="Schram M" first="Mandy" last="Schram">Mandy Schram</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Academic Medical Center, Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Allsopp, Richard" sort="Allsopp, Richard" uniqKey="Allsopp R" first="Richard" last="Allsopp">Richard Allsopp</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Astellas Pharma Europe Ltd, Lovett House, Staines</wicri:regionArea><wicri:noRegion>Staines</wicri:noRegion></affiliation></author><author><name sortKey="Aoki, Valeria" sort="Aoki, Valeria" uniqKey="Aoki V" first="Valeria" last="Aoki">Valeria Aoki</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Dermatology, University of Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Apfelbacher, Christian" sort="Apfelbacher, Christian" uniqKey="Apfelbacher C" first="Christian" last="Apfelbacher">Christian Apfelbacher</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Sociology, Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Social Medicine, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bruijnzeel Oomen, Carla" sort="Bruijnzeel Oomen, Carla" uniqKey="Bruijnzeel Oomen C" first="Carla" last="Bruijnzeel-Koomen">Carla Bruijnzeel-Koomen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, University Hospital Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Bruin Eller, Marjolein" sort="Bruin Eller, Marjolein" uniqKey="Bruin Eller M" first="Marjolein" last="Bruin-Weller">Marjolein Bruin-Weller</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Charman, Carolyn" sort="Charman, Carolyn" uniqKey="Charman C" first="Carolyn" last="Charman">Carolyn Charman</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Dermatology, Royal Devon and Exeter Hospital, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Arnon" sort="Cohen, Arnon" uniqKey="Cohen A" first="Arnon" last="Cohen">Arnon Cohen</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Quality 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type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Furue, Masutaka" sort="Furue, Masutaka" uniqKey="Furue M" first="Masutaka" last="Furue">Masutaka Furue</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Kyushu University, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Gieler, Uwe" sort="Gieler, Uwe" uniqKey="Gieler U" first="Uwe" last="Gieler">Uwe Gieler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Justus Liebig University Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Hooft, Lotty" sort="Hooft, Lotty" uniqKey="Hooft L" first="Lotty" last="Hooft">Lotty Hooft</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dutch Cochrane Centre, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Humphreys, Rosemary" sort="Humphreys, Rosemary" uniqKey="Humphreys R" first="Rosemary" last="Humphreys">Rosemary Humphreys</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Eczema Society, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ishii, Henrique Akira" sort="Ishii, Henrique Akira" uniqKey="Ishii H" first="Henrique Akira" last="Ishii">Henrique Akira Ishii</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Mining Engineering and Petroleum, Polytechnic School of the University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Katayama, Ichiro" sort="Katayama, Ichiro" uniqKey="Katayama I" first="Ichiro" last="Katayama">Ichiro Katayama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Osaka University, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Kouwenhoven, Willem" sort="Kouwenhoven, Willem" uniqKey="Kouwenhoven W" first="Willem" last="Kouwenhoven">Willem Kouwenhoven</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dutch consumers organisation VMCE</wicri:regionArea></affiliation></author><author><name sortKey="Langan, Sinead" sort="Langan, Sinead" uniqKey="Langan S" first="Sinéad" last="Langan">Sinéad Langan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St John's Institute of Dermatology, Guy's and St Thomas’ Hospitals NHS Foundation Trust, UK, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lewis Ones, Sue" sort="Lewis Ones, Sue" uniqKey="Lewis Ones S" first="Sue" last="Lewis-Jones">Sue Lewis-Jones</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Dermatology, Ninewells Hospital & Medical School, DundeeTayside</wicri:regionArea><wicri:noRegion>DundeeTayside</wicri:noRegion></affiliation></author><author><name sortKey="Merhand, Stephanie" sort="Merhand, Stephanie" uniqKey="Merhand S" first="Stephanie" last="Merhand">Stephanie Merhand</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>French Association of Eczema, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Murota, Hiroyuki" sort="Murota, Hiroyuki" uniqKey="Murota H" first="Hiroyuki" last="Murota">Hiroyuki Murota</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Osaka University, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Murrell, Dedee F" sort="Murrell, Dedee F" uniqKey="Murrell D" first="Dedee F." last="Murrell">Dedee F. Murrell</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dermatology, St George Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, NSW, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Nankervis, Helen" sort="Nankervis, Helen" uniqKey="Nankervis H" first="Helen" last="Nankervis">Helen Nankervis</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre of Evidence Based Dermatology, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Ohya, Yukihiro" sort="Ohya, Yukihiro" uniqKey="Ohya Y" first="Yukihiro" last="Ohya">Yukihiro Ohya</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Allergy, Department of Medical Subspecialties, National Centre for Child Health and Development, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Oranje, Arnold" sort="Oranje, Arnold" uniqKey="Oranje A" first="Arnold" last="Oranje">Arnold Oranje</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pediatrics, Division of Pediatric Dermatology, Department of Dermatology, Erasmus MC‐Sophia Children's Hospital, Maasstad Ziekenhuis, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Otsuka, Hiromi" sort="Otsuka, Hiromi" uniqKey="Otsuka H" first="Hiromi" last="Otsuka">Hiromi Otsuka</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Japan Allergy Volunteer Association, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Paul, Carle" sort="Paul, Carle" uniqKey="Paul C" first="Carle" last="Paul">Carle Paul</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Larrey Hospital, Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Rosenbluth, Yael" sort="Rosenbluth, Yael" uniqKey="Rosenbluth Y" first="Yael" last="Rosenbluth">Yael Rosenbluth</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Chief Physician Office, Clalit Health Services, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Saeki, Hidehisa" sort="Saeki, Hidehisa" uniqKey="Saeki H" first="Hidehisa" last="Saeki">Hidehisa Saeki</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, The Jikei University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Schuttelaar, Marie Ouise" sort="Schuttelaar, Marie Ouise" uniqKey="Schuttelaar M" first="Marie-Louise" last="Schuttelaar">Marie-Louise Schuttelaar</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Stalder, Jean Rancois" sort="Stalder, Jean Rancois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Nantes University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Svensson, Ke" sort="Svensson, Ke" uniqKey="Svensson " first=" Ke" last="Svensson"> Ke Svensson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Dermatology, University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Dermatology, School of Medicine, University of Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Wahlgren, Carl Redrik" sort="Wahlgren, Carl Redrik" uniqKey="Wahlgren C" first="Carl-Fredrik" last="Wahlgren">Carl-Fredrik Wahlgren</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine Solna, Dermatology Unit, Karolinska Institutet and Karolinska University Hospital, Solna</wicri:regionArea><wicri:noRegion>Solna</wicri:noRegion></affiliation></author><author><name sortKey="Weidinger, Stephan" sort="Weidinger, Stephan" uniqKey="Weidinger S" first="Stephan" last="Weidinger">Stephan Weidinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig‐Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, Ludwig‐Maximilian‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Williams, Hywel" sort="Williams, Hywel" uniqKey="Williams H" first="Hywel" last="Williams">Hywel Williams</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre of Evidence Based Dermatology, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Dermatology, Nottingham University Hospitals NHS Trust, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Allergy</title><title level="j" type="alt">ALLERGY</title><idno type="ISSN">0105-4538</idno><idno type="eISSN">1398-9995</idno><imprint><biblScope unit="vol">67</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1111">1111</biblScope><biblScope unit="page" to="1117">1117</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2012-09">2012-09</date></imprint><idno type="ISSN">0105-4538</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-4538</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adequate measurements</term><term>Allergy</term><term>Ares</term><term>Atopic</term><term>Atopic dermatitis</term><term>Atopic eczema</term><term>Atopic eczema outcomes research</term><term>Atopic eczema research</term><term>Atopic eczema trials</term><term>Biomarkers</term><term>Clinical signs</term><term>Clinical trials</term><term>Consensus</term><term>Consensus study</term><term>Consensus voting</term><term>Core domain</term><term>Core domains</term><term>Core outcome domain</term><term>Core outcome domains</term><term>Core outcome measures</term><term>Delphi</term><term>Delphi exercise</term><term>Dermatitis</term><term>Dermatol</term><term>Dermatology</term><term>Disease severity</term><term>Domain</term><term>Eczema</term><term>Future atopic eczema trials</term><term>Harmonising outcome measures</term><term>Home group</term><term>Home initiative</term><term>Hywel williams</term><term>Jochen schmitt</term><term>John wiley sons</term><term>John wiley sons schmitt</term><term>Omeract</term><term>Omeract group</term><term>Outcome domains</term><term>Outcome measures</term><term>Outcomes research</term><term>Patient representatives</term><term>Pharmaceutical industry</term><term>Pharmaceutical industry representatives</term><term>Phyllis spuls</term><term>Preliminary core</term><term>Schmitt</term><term>Severity</term><term>Severity index</term><term>Spuls</term><term>Stakeholder</term><term>Systematic review</term><term>Treatment utilization</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adequate measurements</term><term>Allergy</term><term>Ares</term><term>Atopic</term><term>Atopic dermatitis</term><term>Atopic eczema</term><term>Atopic eczema outcomes research</term><term>Atopic eczema research</term><term>Atopic eczema trials</term><term>Biomarkers</term><term>Clinical signs</term><term>Clinical trials</term><term>Consensus</term><term>Consensus study</term><term>Consensus voting</term><term>Core domain</term><term>Core domains</term><term>Core outcome domain</term><term>Core outcome domains</term><term>Core outcome measures</term><term>Delphi</term><term>Delphi exercise</term><term>Dermatitis</term><term>Dermatol</term><term>Dermatology</term><term>Disease severity</term><term>Domain</term><term>Eczema</term><term>Future atopic eczema trials</term><term>Harmonising outcome measures</term><term>Home group</term><term>Home initiative</term><term>Hywel williams</term><term>Jochen schmitt</term><term>John wiley sons</term><term>John wiley sons schmitt</term><term>Omeract</term><term>Omeract group</term><term>Outcome domains</term><term>Outcome measures</term><term>Outcomes research</term><term>Patient representatives</term><term>Pharmaceutical industry</term><term>Pharmaceutical industry representatives</term><term>Phyllis spuls</term><term>Preliminary core</term><term>Schmitt</term><term>Severity</term><term>Severity index</term><term>Spuls</term><term>Stakeholder</term><term>Systematic review</term><term>Treatment utilization</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Allergie</term><term>Industrie pharmaceutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence‐based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence‐based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long‐term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>France</li><li>Israël</li><li>Japon</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>Californie</li><li>District de Dresde</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Groningue (province)</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Kyūshū</li><li>Midi-Pyrénées</li><li>Nottinghamshire</li><li>Nouvelle-Galles du Sud</li><li>Occitanie (région administrative)</li><li>Pays de la Loire</li><li>Préfecture de Fukuoka</li><li>Région de Kantō</li><li>Saxe (Land)</li><li>Schleswig-Holstein</li><li>Utrecht (province)</li><li>État de São Paulo</li></region><settlement><li>Amsterdam</li><li>Dresde</li><li>Fukuoka</li><li>Groningue</li><li>Heidelberg</li><li>Kiel</li><li>Londres</li><li>Munich</li><li>Nantes</li><li>Nottingham</li><li>Rotterdam</li><li>San Diego</li><li>Sydney</li><li>São Paulo</li><li>Tokyo</li><li>Toulouse</li><li>Utrecht</li></settlement><orgName><li>Université de Kyūshū</li><li>Université de Nottingham</li><li>Université de São Paulo</li></orgName></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name></region><name sortKey="Apfelbacher, Christian" sort="Apfelbacher, Christian" uniqKey="Apfelbacher C" first="Christian" last="Apfelbacher">Christian Apfelbacher</name><name sortKey="Apfelbacher, Christian" sort="Apfelbacher, Christian" uniqKey="Apfelbacher C" first="Christian" last="Apfelbacher">Christian Apfelbacher</name><name sortKey="Gieler, Uwe" sort="Gieler, Uwe" uniqKey="Gieler U" first="Uwe" last="Gieler">Uwe Gieler</name><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><name sortKey="Weidinger, Stephan" sort="Weidinger, Stephan" uniqKey="Weidinger S" first="Stephan" last="Weidinger">Stephan Weidinger</name><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Spuls, Phyllis" sort="Spuls, Phyllis" uniqKey="Spuls P" first="Phyllis" last="Spuls">Phyllis Spuls</name></region><name sortKey="Boers, Maarten" sort="Boers, Maarten" uniqKey="Boers M" first="Maarten" last="Boers">Maarten Boers</name><name sortKey="Bruijnzeel Oomen, Carla" sort="Bruijnzeel Oomen, Carla" uniqKey="Bruijnzeel Oomen C" first="Carla" last="Bruijnzeel-Koomen">Carla Bruijnzeel-Koomen</name><name sortKey="Bruin Eller, Marjolein" sort="Bruin Eller, Marjolein" uniqKey="Bruin Eller M" first="Marjolein" last="Bruin-Weller">Marjolein Bruin-Weller</name><name sortKey="Hooft, Lotty" sort="Hooft, Lotty" uniqKey="Hooft L" first="Lotty" last="Hooft">Lotty Hooft</name><name sortKey="Kouwenhoven, Willem" sort="Kouwenhoven, Willem" uniqKey="Kouwenhoven W" first="Willem" last="Kouwenhoven">Willem Kouwenhoven</name><name sortKey="Oranje, Arnold" sort="Oranje, Arnold" uniqKey="Oranje A" first="Arnold" last="Oranje">Arnold Oranje</name><name sortKey="Roekevisch, Evelien" sort="Roekevisch, Evelien" uniqKey="Roekevisch E" first="Evelien" last="Roekevisch">Evelien Roekevisch</name><name sortKey="Schram, Mandy" sort="Schram, Mandy" uniqKey="Schram M" first="Mandy" last="Schram">Mandy Schram</name><name sortKey="Schuttelaar, Marie Ouise" sort="Schuttelaar, Marie Ouise" uniqKey="Schuttelaar M" first="Marie-Louise" last="Schuttelaar">Marie-Louise Schuttelaar</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Thomas, Kim" sort="Thomas, Kim" uniqKey="Thomas K" first="Kim" last="Thomas">Kim Thomas</name></region><name sortKey="Allsopp, Richard" sort="Allsopp, Richard" uniqKey="Allsopp R" first="Richard" last="Allsopp">Richard Allsopp</name><name sortKey="Chalmers, Joanne" sort="Chalmers, Joanne" uniqKey="Chalmers J" first="Joanne" last="Chalmers">Joanne Chalmers</name><name sortKey="Charman, Carolyn" sort="Charman, Carolyn" uniqKey="Charman C" first="Carolyn" last="Charman">Carolyn Charman</name><name sortKey="Flohr, Carsten" sort="Flohr, Carsten" uniqKey="Flohr C" first="Carsten" last="Flohr">Carsten Flohr</name><name sortKey="Flohr, Carsten" sort="Flohr, Carsten" uniqKey="Flohr C" first="Carsten" last="Flohr">Carsten Flohr</name><name sortKey="Humphreys, Rosemary" sort="Humphreys, Rosemary" uniqKey="Humphreys R" first="Rosemary" last="Humphreys">Rosemary Humphreys</name><name sortKey="Langan, Sinead" sort="Langan, Sinead" uniqKey="Langan S" first="Sinéad" last="Langan">Sinéad Langan</name><name sortKey="Langan, Sinead" sort="Langan, Sinead" uniqKey="Langan S" first="Sinéad" last="Langan">Sinéad Langan</name><name sortKey="Lewis Ones, Sue" sort="Lewis Ones, Sue" uniqKey="Lewis Ones S" first="Sue" last="Lewis-Jones">Sue Lewis-Jones</name><name sortKey="Nankervis, Helen" sort="Nankervis, Helen" uniqKey="Nankervis H" first="Helen" last="Nankervis">Helen Nankervis</name><name sortKey="Williams, Hywel" sort="Williams, Hywel" uniqKey="Williams H" first="Hywel" last="Williams">Hywel Williams</name><name sortKey="Williams, Hywel" sort="Williams, Hywel" uniqKey="Williams H" first="Hywel" last="Williams">Hywel Williams</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Aoki, Valeria" sort="Aoki, Valeria" uniqKey="Aoki V" first="Valeria" last="Aoki">Valeria Aoki</name></region><name sortKey="Ishii, Henrique Akira" sort="Ishii, Henrique Akira" uniqKey="Ishii H" first="Henrique Akira" last="Ishii">Henrique Akira Ishii</name><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name></country><country name="Israël"><noRegion><name sortKey="Cohen, Arnon" sort="Cohen, Arnon" uniqKey="Cohen A" first="Arnon" last="Cohen">Arnon Cohen</name></noRegion><name sortKey="Rosenbluth, Yael" sort="Rosenbluth, Yael" uniqKey="Rosenbluth Y" first="Yael" last="Rosenbluth">Yael Rosenbluth</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Dohil, Magdalene" sort="Dohil, Magdalene" uniqKey="Dohil M" first="Magdalene" last="Dohil">Magdalene Dohil</name></region></country><country name="Japon"><region name="Kyūshū"><name sortKey="Furue, Masutaka" sort="Furue, Masutaka" uniqKey="Furue M" first="Masutaka" last="Furue">Masutaka Furue</name></region><name sortKey="Katayama, Ichiro" sort="Katayama, Ichiro" uniqKey="Katayama I" first="Ichiro" last="Katayama">Ichiro Katayama</name><name sortKey="Murota, Hiroyuki" sort="Murota, Hiroyuki" uniqKey="Murota H" first="Hiroyuki" last="Murota">Hiroyuki Murota</name><name sortKey="Ohya, Yukihiro" sort="Ohya, Yukihiro" uniqKey="Ohya Y" first="Yukihiro" last="Ohya">Yukihiro Ohya</name><name sortKey="Otsuka, Hiromi" sort="Otsuka, Hiromi" uniqKey="Otsuka H" first="Hiromi" last="Otsuka">Hiromi Otsuka</name><name sortKey="Saeki, Hidehisa" sort="Saeki, Hidehisa" uniqKey="Saeki H" first="Hidehisa" last="Saeki">Hidehisa Saeki</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Merhand, Stephanie" sort="Merhand, Stephanie" uniqKey="Merhand S" first="Stephanie" last="Merhand">Stephanie Merhand</name></region><name sortKey="Paul, Carle" sort="Paul, Carle" uniqKey="Paul C" first="Carle" last="Paul">Carle Paul</name><name sortKey="Stalder, Jean Rancois" sort="Stalder, Jean Rancois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Murrell, Dedee F" sort="Murrell, Dedee F" uniqKey="Murrell D" first="Dedee F." last="Murrell">Dedee F. Murrell</name></region><name sortKey="Murrell, Dedee F" sort="Murrell, Dedee F" uniqKey="Murrell D" first="Dedee F." last="Murrell">Dedee F. Murrell</name></country><country name="Suède"><noRegion><name sortKey="Svensson, Ke" sort="Svensson, Ke" uniqKey="Svensson " first=" Ke" last="Svensson"> Ke Svensson</name></noRegion><name sortKey="Wahlgren, Carl Redrik" sort="Wahlgren, Carl Redrik" uniqKey="Wahlgren C" first="Carl-Fredrik" last="Wahlgren">Carl-Fredrik Wahlgren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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